The truth about antibiotics and COPD

The evidence for antibiotics in COPD exacerbations has never been strong, yet it remains a core part of many management guidelines internationally. An article in JAMA brings up the issue, noting that ‘…the evidence is based on small, heterogenous trials, few of which based on hospitalised patients.’

The article looks at antibiotic therapy and treatment failure, and shows that antibiotics lowered the rates of mechanical ventilation, mortality, and readmission. The multivariate analysis showed that antibiotics were protective, with an odds ratio of 0.87. The rates of C. difficile diarrhoea were higher though, and there’s no telling the effects this will have on antibiotic resistance…

Read the full article here. For more, check out the coverage on Medscape here


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