Long term metformin leads to B12 deficiency

Metformin is a commonly used oral hypoglycaemic agent used in the treatment of diabetes, and many guidelines suggest it as first line pharmacotherapy.
This article out of the BMJ notes that metformin treatment leads to a mean decrease of vitamin B12 levels of 19%, as well as a mild increase in homocysteine. Metformin appears to interfere with the absorption of B12, leading to the decreased levels. 


Keep a close eye on the B12 levels of your patients on metformin – anticipate and prevent any complications.


Read the article at the BMJ here

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