Using both ACE inhibitors and angiotensin receptor blockers in diabetic nephropathy

ACE inhibitors are the first line drug for control of hypertension in diabetics, with a plethora of benefits including the reduction of proteinuria. The follow on question then is whether adding an A2 receptor blocker will help further – and this article gives you the answer.

Basically, it’s not recommended. Even though there was a small trend toward benefit in regards to first occurrence of  decline in eGFR, the trial was stopped early due to increased hyperkalaemia and development of acute kidney injury.

Have a read of the full thing over here.

 

source | New England Journal of Medicine

image | Wikimedia Commons

 

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