ACE inhibitors are the first line drug for control of hypertension in diabetics, with a plethora of benefits including the reduction of proteinuria. The follow on question then is whether adding an A2 receptor blocker will help further – and this article gives you the answer.
Basically, it’s not recommended. Even though there was a small trend toward benefit in regards to first occurrence of decline in eGFR, the trial was stopped early due to increased hyperkalaemia and development of acute kidney injury.
Have a read of the full thing over here.
source | New England Journal of Medicine
image | Wikimedia Commons