review | immunotherapy for melanoma

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Immunotherapy for melanoma has revolutionised the treatment options for what can be a devastating disease – you’ve seen that we’ve talked time and time again about the newer agents that can be used. But what exactly is their role? Continue reading

Paroxysmal nocturnal haemoglobinuria and its complications

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Look how this article begins:

“A 24-year-old medical editor presented to her primary care physician with fevers, epigastric pain, nausea, and vomiting upon returning from a business trip…”

I’d be surprised if your first thought was PNH. In fact, not only is PNH quite rare but the ‘classic triad’ of symptoms is not always present – intravascular haemolysis, thrombosis, and cytopaenia. The key therapy is eculizumab, which really revolutionized therapy, thanks to the SHEPHERD and TRIUMPH trials.  Continue reading

review | asthma

The Lancet has often got great reviews in its Seminar series, and this month is no different. Prof. Martinez and Prof. Vercelli from Arizona have provided us with a nice summary of the old and the new when it comes to asthma, with some nice insights into severe asthma. Read it here.

 

source | The Lancet

image | NIAID

Doing percutaneous coronary intervention – without a surgical backup

In the early days of percutaneous intervention – stenting and so on – you’d always want to have cardiothoracics around to crack the chest in case of emergency bypass surgery. As the population gets larger, and further away from major centres, more places are doing diagnostic angiography, and some of them are starting to stent.  This month’s NEJM has a look at the safety of doing PCI without surgical backup. Continue reading