Atrial fibrillation as a risk factor for myocardial infarction

File:A-fib.png

We all know that ischaemic heart disease is a risk factor for AF, through multiple mechanisms, however how about AF as a risk factor for having an MI?

Turns out AF doubles your risk (1.7 after adjustment for major risk factors). This association was stronger in women, and not significant in the older age group.

It’s not just strokes – AF is becoming a serious public health issue, and one we don’t know enough about. Read more at JAMA Internal Medicine.

 

image | Wikimedia Commons

source | JAMA Internal Medicine

 

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Bisphosphonates increase the risk of the development of atrial fibrillation

Bisphosphonates are often the go-to- therapy for osteoporosis, despite recent claims regarding the risk of atypical fractures with prolonged use. Newer agents such as denosumab are certainly breaking onto the scene, but haven’t quite found their place yet. This meta-analysis from CHEST looked at the association between bisphosphonate use and the onset of atrial fibrillation, as well as its complications.

Looking at six observation studies and six randomised trials, there was certainly a statistically significant risk of osteoporosis (between 1.27 and 1.4), but no increase in stroke or cardiovascular mortality. An interesting result and the pathophysiology behind this would be fascinating.

Read more over at CHEST, here.

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